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KMID : 0376219810180030377
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Chonnam Medical Journal
1981 Volume.18 No. 3 p.377 ~ p.387
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Phagocytic Activity and Experimental Liver Injury in Splenectomized Rat
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Abstract
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The experiment is designed to investigate the effect of splenectomy on the hepatotoxicity induced by prednisolone.
Experimental groups are divided into non-splenectomized and splenectomized rats treated with prednisolone(2mg/kg/day) for three days.
The RES function test using carbon clearance method, liver function tests (SGOT & BSP) and morphologic investigation have been carried out at sixth hour and on the first, second, third and seventh day after final treatment.
The results are as follows.
1. The phagocytic activity of RES in non-splenectomized rats is considerably decreased on the second day and is relatively recovered on the seventh day. The phagocytic activity is more decreased in non-splenectomized rats than in splenectomized rats.
2. The levels of SGOT and BSP are elevated in both groups, and more in non-splenectomized rats than in splenectomized rats.
3. The morphologic changes of liver consists of various degree of hydropic or fatty degenerations, focal necrosis without inflammatory cell infiltrations. The change is most severe on the second day, and is somewhat milder in splenectomized rats than in non-splenectomized rats.
From these results, it may be concluded that the hepatotoxicity induced by prednisolone tends to be reduced by splenectomy.
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